Production and extracellular arrangement of proteoglycans in the growing hyaline cartilage
Geyer, G.; Linss, W.
Gegenbaurs Morphologisches Jahrbuch 127(5): 625-628
1981
ISSN/ISBN: 0016-5840 PMID: 7343403 Document Number: 176509
Fixation of hyaline cartilage with potassium ferricyanide in addition to glutaraldehyde and osmium tetroxide leads to a better stabilization of the glycosaminoglycans. The resulting chelate formation enhances the electronmicroscopic density. In active chondrocytes electron dense material is found intracellularly in the rough endoplasmic reticulum, in transport vesicles, in the Golgi apparatus and in big vacuoles. Intercellularly large amounts of the glycosaminoglycans are preserved. The correlations between the macromolecules and the collagenous fibrills are demonstrated.