Effect of moderate and high loadings on the proteoglycans and water content of bovine knee joint articular cartilage
Saxena, R.K.; Sahay, K.B.; Guha, S.K.
Indian Journal of Medical Research 100: 201-207
1994
ISSN/ISBN: 0019-5340 PMID: 7851973 Document Number: 438105
Variations in proteoglycans and water content of the knee joint cartilage were found to occur when the joint was subjected to articulating motion under moderate and high loadings. It was found that at a moderate load of 150 kg there were an increase in the percentage of proteoglycans but the percentage decreased when the joint was articulated at a high loading of 300 kg. It has also been observed that the ratio of water content and the proteoglycans decreased at moderate load, whereas the ratio increased at high load. The observed changes in proteoglycans and water content in extracellular matrix with moderate and high loadings suggested that articular cartilage properties respond to mechanical stresses.