Levels of large proteoglycan aggregate binding proteins and the level of small proteoglycans in healthy human articular cartilage and in osteoarthrosis
Valouch, P.; Krajícková, J.
Casopis Lekaru Ceskych 129(47): 1488-1489
1990
ISSN/ISBN: 0008-7335 PMID: 2257594 Document Number: 348381
The investigation was focused on the electronmicroscopic localization of one structure of the aggregate of the large proteoglycan--binding proteins and the small dermatan sulphate proteoglycan, using specific antibodies prepared against these structures and the complex colloid gold--protein A. The authors investigated the incidence and distribution of these structures in the intercellular area of ultrathin sections of the sound and arthritic human articular cartilage. In the arthritic cartilage, consistent with biochemical findings, the authors detected a loss of the binding protein or its disappearance and conversely an increase of the small dermatan sulphate proteoglycan.