Effects of glycopyrrolate and atropine combined with antacid on gastric acidity
Roper, R.E.; Salem, M.G.
British Journal of Anaesthesia 53(12): 1277-1280
1981
ISSN/ISBN: 0007-0912 PMID: 6274372 Document Number: 175787
Glycopyrrolate, atropine or saline were administered i.v. with oral magnesium trisilicate 1 h before induction of anesthesia to patients about to undergo Cesarean section. Both anticholinergics greatly reduced gastric acidity. It is suggested that glycopyrrolate should be used in combination with antiacid therapy before obstetric anesthesia and puerperal tubal ligation because of its prolonged duration of action, effect on gastric secretion and failure to cross the placental barrier.