The Possible Role of Mast Cells and VEGF in Peritumoural Oedema of Secretory Meningioma
Tirakotai, W.; Mennel, H.-D.; Lapanich, S.; Sure, U.; Bertalanffy, H.; Celik, I.
Journal of the Medical Association of Thailand 99(Suppl 3): S8-115
2016
ISSN/ISBN: 0125-2208 PMID: 29901331 Document Number: 17569
Secretory meningiomas constitute a relatively rare subtype of meningiomas and present often with massive peritumoural oedema. From our previous report, a high number of mast cells were demonstrable in this subtype of meningiomas. The present study aimed to obtain more information about mast cell derived progangiogenic factors and mediators as well as VEGF receptors in secretory meningioma. Additionally, the correlation of histological factors such as the presence of mast cells and the radiological evidence of surrounding tumour oedema was analysed. Sixteen cases of secretory meningioma were examined. Relevant clinical information was obtained from the patient files. The peritumoural oedema was determined either by CT or MRI scans and graded as mild, moderate and severe. Immunohistochemical studies of histamine, substance P, serotonin, VEGF and VEGF receptors were performed. A There was no immunoreactivity against histamine or substance P within the tumour tissue or in mast cells. Fine Secretory meningiomas are characterized by a significantly increased number of mast cells. VEGF and serotonin might be involved in the pathophysiological process of this vasogenic brain oedema. The preliminary data demonstrated the potential relation between the radiological evidence of increasing oedema and the high numbers of mast cell staining positively for VEGF.