The Possibility of Developing Screening Criteria for Patients Suspected Multiple Myeloma (MM) at Thammasat University Hospital
Kanitsap, N.; Umpunthongsiri, S.
Journal of the Medical Association of Thailand 99 Suppl. 4: S189-S194
2016
ISSN/ISBN: 0125-2208 PMID: 29926710 Document Number: 17568
Patients suspected with multiple myeloma (MM) are often delayed investigation and diagnosis because of multiple factors. The objective of this study was to evaluate factors leading to diagnosis of MM would help in early diagnosis and treatments. To evaluate the effectiveness of factors used for myeloma screening and to find any factors that can predict the diagnosis of multiple myeloma. From Aug 2013 to Mar 2015, 300 patients were enrolled into this study. Every patient must have met the criteria of: 1) age above 50 years, 2) at least one of laboratory criteria (Hb <10 g/dL, serum creatinine >2 mg/dL, serum calcium >10 mg/dL), and 3) at least one skeletal criterion (bone pain, osteoporosis or history of fracture). Eligible patients' sample were sent for serum protein electrophoresis (SPEP) to screen for MM. From 300 patients, there were 70 patients (23.3%) diagnosed with MM. Of the 3 criteria, all patients (n = 300, Among many factors those are the common presentation of MM, there were no factor or combination of factors that shown statistically significant to predict the diagnosis of multiple myeloma. However, we would suggest thinking of MM in elderly patients who have bone pain or osteoporosis, hypercalcemia, and azothemia or renal failure.