Effect of polyanions on macrophage-lymphocyte interaction
Lysenko, A.I.; Kulakova, G.S.; Romanova, M.V.; Cherniavskiĭ, V.I.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2: 84-87
1981
ISSN/ISBN: 0372-9311 PMID: 6166138 Document Number: 175561
The effect of polyanions on the interaction of antigen-stimulated macrophages and lymphocytes was studied in vivo. Treatment of cell mixture of macrophages and lymphocytes with poly = A : U or dextran sulfate induced a considerable increase in the number of lymphocytes contacting with macrophages during the first hours of cultivation. Under similar conditions yeast RNA had a certain anticooperative effect. According to the data obtained by scanning electron microscopy, the contacts between the interacting cells were realized by means of cytoplasmic bridges or close membrane connections.