Teratogenic effect of the fungicide calixin
Shtenberg, A.I.; Zaeva, G.N.; Rysina, T.Z.; Gavrilenko, E.V.
Voprosy Pitaniia 40(6): 55-61
1981
ISSN/ISBN: 0042-8833 PMID: 7324433 Document Number: 175538
Experimental studies on Wistar rats revealed that the fungicide calixin (N-tridecyl-2,6-dimethylmorpholine) has a teratogenic effect. This effect manifested in edemas, hemorrhages, hematomas, abnormal development of the brain (hydrocephalus), visceral cranium (micrognathia, cleft palate) and genitourinary system (hydronephrosis), in decreased size of pelvic bones, shoulder girdle, front and hind limbs, etc. Marked teratogenic effect was in good agreement with the dose. Threshold and subthreshold doses of calixin, in terms of the teratogenic effect, were 0.6 and 0.13 mg/kg, respectively. Calixin produces a clear-cut, specific teratogenic effect that is evidenced by a wide spectrum of specific action (class I of extremely hazardous substances). The most pronounced changes were induced by calixin administration during the entire period of pregnancy (days 1-20) as compared to its administration during organogenesis (days 7-15).