Evaluation of serum BuChe activity during polychemotherapy based on COP and C-MOPP protocols
Fazio, M.; Airoldi, M.; Bellardo, A.; Cavallero, P.; Mastromatteo, V.; Minnella, R.; Pecchio, F.
Bollettino della Societa Italiana di Biologia Sperimentale 57(24): 2512-2518
1981
ISSN/ISBN: 0037-8771 PMID: 7337762 Document Number: 175520
The Authors have evaluated the serum cholinesterase activity in patients subjected to 2 different schemes of polychemotherapy: COP (CTX, VCR, Prednisone) and C-MOPP (CTX, VCR, PCZ, Prednisone). The two schemes involve the administration of cyclophosphamide that, as has already been proved, significantly lowers serum cholinesterase level after only a few hours. The Authors have observed that the combination of cyclophosphamide with other antiblastic drugs or a longer treatment have little influence on the down curve of the serum cholinesterase in relation to what they have observed after treatment with cyclophosphamide alone.