Evaluation of the renal function in patients with ovarian carcinoma subjected to polychemotherapy including cisplatin or carboplatin
Gadducci, A.; Facchini, V.; Dell'Arciprete, T.; Del Bravo, B.; Galigani, P.; Palla, R.; Fioretti, P.
Minerva Ginecologica 40(1): 33-38
1988
ISSN/ISBN: 0026-4784 PMID: 3287233 Document Number: 4115
The aim of this study was to compare the nephrotoxicity of Cisplatin (DDP) and Carboplatin (JM-8) in patients with advanced ovarian carcinoma. Fifteen patients were treated with DDP (50 mg/mq i.v. 1st day) + Adriamycin (ADM) (45-50 mg/mq i.v. 1st day) + Cyclophosphamide (CTX) (600 mg/mq i.v. 1st clay) every 28 days for 6 cycles (PAC arm). Four patients were treated with JM-8 (200 mg/mq i.v. 1st day) + ADM (45 mg/mq i.v. 1st day) + CTX (600 mg/mq i.v. 1st day) every 28 days for 6 cycles. Patients in PAC arm were administered two litres of 5 0/0 destrose solution intravenously. Diuresis with mannitol and furosemide was also induced. JM-8 was administered without hydration and forced diuresis. Before and after every cycle, creatinine clearance, Na' excretional fraction rate (N'EFR) and urinary N-Acetyl-ßGlucosaminidase (NAG), Gamma-Glutamil-Transpeptidase (GGT) and Lactic-Dehydrogenase (LDH) concentrations were evaluated. In PAC arm creatinine clearance and Na'EFR significantly reduced after chemotherapy and returned to the starting values before the following cycle. NAG and GGT showed a significant increase after DDP infusion and returned normal before the next cycle. In JAC arm creatinine clearance and Na'EFR showed a lower decrease than in PAC one. GGT significantly increased after JM-8 administration and returned in the normal range before the next cycle, while NAG did not show significant changes. In conclusion with the above described regimen of administration, DDP induces an acute but reversible nephrotoxic side effect. Furthermore our preliminary data seem to confirm the lower nephrotoxicity of JM-8 although it was administered without any hydration or forced diuresis.
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