Congenital hepatic fibrosis: a disease with diverse manifestations
Ghishan, F.K.; Younoszai, M.K.
American Journal of Gastroenterology 75(4): 317-320
1981
ISSN/ISBN: 0002-9270 PMID: 7196150 Document Number: 174560
We present four pediatric patients with histologically proven congenital hepatic fibrosis. The patients had diverse manifestations. The first two patients were seven-year old identical twins who presented with hepatosplenomegaly and were found to have portal hypertension with esophageal varices. The third patient was a newborn who had intractable ascites, secondary to portal hypertension. The fourth patient was a seven-year old with adult type polycystic disease of the kidney but no evidence of portal hypertension. Contrary to what has been reported in the literature of the appearance of portal hypertension in the late childhood period, congenital hepatic fibrosis may present in any age group with portal hypertension.