Midazolam for the treatment of phantom limb pain exacerbation: preliminary reports
Vichitrananda, C.; Pausawasdi, S.
Journal of the Medical Association of Thailand 84(2): 299-302
2001
ISSN/ISBN: 0125-2208 PMID: 11336093 Document Number: 1745
Phantom pain is one of the most difficult intractable pains to manage. The pain may result from the imbalance of self-sustaining neural activity that exceeds the inhibitory control. The management of acute severe exacerbation of phantom pain is extremely difficult. Midazolam acts by potentiation of gamma aminobutyric acid (GABA) and enhance the inhibitory action of glycine receptor at spinal neurons. We describe two preliminary reports of complete pain relief of severe phantom pain exacerbation by intravenous midazolam 3-5 mg.
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