Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin
Ciesielski, L.; Simler, S.; Mandel, P.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 175(1): 109-113
1981
ISSN/ISBN: 0037-9026 PMID: 6452930 Document Number: 174285
Sodium dipropylacetate, an anticonvulsant used in human therapy, gives a more efficient protection against convulsions elicited by pentetrazol than by picrotoxin. In the case of picrotoxin induced convulsive seizures where there is an alteration at the GABA receptor level, ther is a lack of efficiency after nDPA treatment which increases GABA at the synaptic level. DPA is more effective against pentetrazol convulsive seizures where no direct participation of GABAergic receptors seems to occur. The efficiency of potentialisation of GABAergic mediation is a function of the mechanism by which the seizure is triggered.