Hypernatraemia, diabetes mellitus, hyperprolactinaemia, retarded growth and delayed puberty in a 14 year old girl. Effect of bromocriptine treatment
Christensen, N.C.; Hagen, C.; Nielsen, M.D.; Petersen, S.
Acta Endocrinologica 96(1): 30-35
1981
ISSN/ISBN: 0001-5598 PMID: 7006294 Document Number: 174284
Investigations in a 14 yr old girl with arrested growth for 2 yr, delayed pubertal development, hypernatremia without thirst, diabetes mellitus and hyperlipemia are reported. The hypernatremia was accompanied by a low vasopressin concentration with an abnormal response to thirst, high plasma renin and normal plasma aldosterone concentrations. Treatment with vasopressin and increased fluid intake decreased serum Na levels. Serum gonadotropins were low; growth hormone response during an insulin tolerance test was subnormal and basal serum prolactin concentration was elevated. Bone age, thyroid function and adrenal function were normal. After initiation of bromocriptine treatment, her growth accelerated and regular menstruations commenced. The serum gonadotropin levels increased and showed pulsatile release. A hypothalamic disorder is suggested, but no cerebral lesion could be demonstrated.