Oscillatory potential and renal function in adult-onset diabetes mellitus
Okumura, T.; Yonemura, D.; Kawasaki, K.; Ishida, H.; Kido, M.
Nippon Ganka Gakkai Zasshi 85(11): 2046-2053
1981
ISSN/ISBN: 0029-0203 PMID: 7337126 Document Number: 174168
The oscillatory potential (OP) of electroretinogram (ERG) is very susceptible to retinal disturbance in diabetes mellitus. Retinopathy and nephropathy are well-known complications in diabetes. The correlation between the oscillatory potential and renal function (proteinuria, serum creatinine, blood urea nitrogen [BUN]) in 282 patients with adult-onset diabetes mellitus is described. In diabetic patients having visible retinopathy (Scott I-III), the following was found. The summed amplitude (.SIGMA.O) of the upward deflections (O1-O4) of the oscillatory potential was more frequently reduced in cases with proteinuria than in cases without (P < 0.01). The mean amplitude .SIGMA.O was significantly smaller in cases with proteinuria than in cases without proteinuria (P < 0.05). The mean peak latency of O1 was significantly longer in cases with proteinuria than in cases without proteinuria (P < 0.01). The mean amplitude .SIGMA.O was smaller in cases with abnormal serum creatinine level (> 1.2 mg/dl) than in cases with normal serum creatinine level (below 1.2 mg/dl) (P < 0.05). The mean amplitude .SIGMA.O was smaller in cases with abnormal BUN level (> 21 mg/dl) than in cases with normal BUN level (< 21 mg/dl) (P < 0.05). The interpeak interval between O1 and O2 was more frequently prolonged in cases with abnormal BUN level than in cases with normal BUN level (P < 0.01). The mean interpeak interval between O1 and O2 was significantly longer in cases with abnormal BUN level than in cases with normal BUN level (P < 0.01). In diabetic patients having no visible retinopathy, the amplitude .SIGMA.O was more frequently reduced in cases with abnormal serum creatinine level (> 1.2 mg/dl) than in cases with normal serum creatinin level (< 1.2 mg/dl) (P < 0.05).