Ednit effects on activity of renin-angiotensin-aldosterone system and renal function in hypertensive subjects with diabetes mellitus
Zonis, B.Ia.; Volkova, N.I.; Sokolov, O.Iu.
Terapevticheskii Arkhiv 72(2): 53-55
2000
ISSN/ISBN: 0040-3660 PMID: 10717928 Document Number: 526122
Aim. To evaluate effects of enalapril (enit) therapy on activity and reactivity of renin-angiotensin-aldosteron system (RAAS) and renal function. Materials and methods. Ednit was given in a dose 5-10 mg/day to 30 patients with mild or moderate arterial hypertension (AH) in combination with moderate or severe non-insulin-dependent diabetes mellitus (NIDDM) in compensation or subcompensation of carbohydrate metabolism. Results. Ednit lowered blood pressure after 6-7 days of treatment. Normal blood pressure was achieved on the treatment week 4-6. Antihypertensive effect of ednit resulted from a significant reduction in a total peripheral vascular resistance under unchanged cardiac output. Adequate hypoglycemic and antihypertensive therapy normalized carbohydrate metabolism. Renal elimination of nitrogen did not change much. glomerular filtration rate in patients with hyper- and hypofiltration returned to normal. Proteinuria reduced, microalbuminuria was not registered. RAAS activity normalized. Conclusion. Ednit has both high antihypertensive activity and marked renoprotective effect with minor influence on carbohydrate metabolism in AH patients with NIDDM.