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Isolation and characteristics of somatic cell hybrids of the Chinese hamster and American mink

Rubtsov, N.B.; Radzhabli, S.I.; Gradov, A.A.; Serov, O.L.

Tsitologiia i Genetika 15(3): 54-58

1981

ISSN/ISBN: 0564-3783
PMID: 6942558
Document Number: 174009
The paper deals with obtaining somatic cell hybrids of Chinese hamster and mink by means of inactivated Sendy virus. 39 hybrid clones segregating mink chromosomes were formed by fusing Chinese hamster cells deficient in hypoxanthine phosphoribosyliransferase with normal cells of mink. Enzyme analyses of these hybrid clones revealed that in mink genes coding lactate dehydrogenase-A, lactate dehydrogenase-B, malate dehydrogenase-NAD (soluble), 6-phosphogluconate dehydrogenase, glucose-6-phosphate dehydrogenase are not syntenic. A possibility of successful utilization of these somatic cell hybrids for mapping mink genes is shown.

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