Repair of DNA-protein cross-links induced by antineoplastic alkylating agents
Lomova, T.I.; Shakhova, I.K.; Shkodinskaia, E.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 92(7): 74-76
1981
ISSN/ISBN: 0365-9615 PMID: 7295949 Document Number: 174008
The bifunctional and antitumor alkylating agents embichin and its aromatic derivatives sarcolysin and chlorfenacyl remarkably differ in DNA-protein cross-links induction in Chinese hamster cell cultures in vitro. The differences involve the concentration necessary for cross-linkage, the time of cross-links emergence, and their reparation. Since all three compounds have the same alkylating group, it is obvious that the differences seen in the cross-linkage arise from the structure of aromatic groupings introduced into the molecule.