Further studies on the immunosuppressive effects of indomethacin
Rojo, J.M.; Barasoain, I.; Portolés, A.
International Journal of Clinical Pharmacology Therapy and Toxicology 19(5): 220-222
1981
ISSN/ISBN: 0174-4879 PMID: 6972923 Document Number: 173950
Oral administration of indomethacin inhibited immune response to sheep red blood cells in mice as assessed by direct plaque-forming cells. Serum titers, subsequent to immunization with Pseudomonas aeruginosa lipopolysaccharide, were also diminished in the indomethacin-treated mice. These effects were independent of both the antigen used as well as the magnitude of the primary immune response obtained. Prostaglandins are suggested to play a positive role in in vivo B cell proliferation and function.