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Serotonin distribution between plasma and platelets in clinically healthy children

Mello, P.; Stagni, S.; Gualandi, S.; Corsini, F.

Bollettino della Societa Italiana di Biologia Sperimentale 57(10): 1062-1067

1981

ISSN/ISBN: 0037-8771
PMID: 7295391
Document Number: 173654
Serotonin distribution between plasma and platelets was examined in 34 clinically healthy children. We measured 5-HT with spectrofluorometric method. We obtained no correlation between plasma and platelets 5-HT. Serotonin is more concentrated in platelets than in plasma. In fact, platelets uptake 5-HT even at low plasma concentration, by an active transport mechanism and store it in granular substructures. 5-HT uptake occurs in similar way both in platelets and in 5-HT neurons. MOreover, the 5-HT receptors react to 5-HT agonist or antagonist drugs as the receptors of some SNC areas (not those with dense 5-HT innervation). Therefore, platelets might be used as indication for 5-HT neurons activity in those SNC regions whose receptors react to drugs as platelets receptors.

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