Platelet adenine nucleotides and arachidonic acid metabolism in the myeloproliferative disorders
Russell, N.H.; Salmon, J.; Keenan, J.P.; Bellingham, A.J.
Thrombosis Research 22(4): 389-397
1981
ISSN/ISBN: 0049-3848 PMID: 6794179 Document Number: 173576
Platelet aggregation to collagen, ADP and arachidonic acid were investigated in 17 patients with various myeloproliferative states. Ten patients who had abnormalities of aggregation to collagen and/or ADP all had diminished intracellular and releasable adenine nucleotides but aggregation to arachidonic acid was normal. Seven patients who had normal aggregation responses had normal platelet adenine nucleotides. In the 10 patients with abnormal platelet function, platelet cyclooxygenase activity was normal but, in 2 patients, platelet lipoxygenase activity was reduced. Thromboxane B2 production during collagen stimulation was normal, suggesting normal release of endogenous arachidonic acid. Platelet defect in myeloproliferative states apparently is due to an acquired storage pool disease.