1,6-Disubstituted 3-methylquinoxalin-2 (1H) -ones. Effect on acquisition and modification of a conditioned avoidance response in the rat
Alamanni, M.C.; Pirisino, G.; Savelli, F.; Sparatore, F.; Manca, P.; Satta, M.
Il Farmaco; Edizione Scientifica 36(5): 359-371
1981
ISSN/ISBN: 0430-0920 PMID: 7238852 Document Number: 173233
Sixteen derivatives of 3-methylquinoxalin-2(1H)-one were prepared; they are variously substituted on position 6 (R = H, COCH3, OCH3, CF3) and bear on position 1 an aminoalkyl chain (dimethylaminoethyl, dimethylaminopropyl, N-methylpiperazinylpropyl and morpholinylethyl). Most of these compounds exhibit a high degree of deconditioning activity on rats; compound (X) is significantly more active than chlorpromazine in the tests used.