Combination of beta-receptor blocking agents and saluretica in outpatient treatment of hypertension. Results of a comparative study
Hoffmann, J.; Schrey, A.; Grund, R.; Forst, T.
Münchener Medizinische Wochenschrift 123(12): 483-488
1981
ISSN/ISBN: 0341-3098 PMID: 6783861 Document Number: 172132
In a randomized single-blind study a comparison was made between the blood pressure lowering effect and the tolerance of two different combinations of beta-blockers and diuretic agents, one of the combinations being given in a sustained-release form. The study was made in 60 out-patients suffering from hypertension of the severity degrees I and II (WHO). The blood pressure reduction achieved as well as the diminution of the increase in heart rate and blood pressure under ergometric load proved to be almost equal in both groups. The number of patients whose blood pressure was normalized by the end of the study was larger in the group treated with Cardiotensin. The influence on laboratory parameters was only minimal and without clinical relevance. Both preparations have generally been well tolerated and exhibited an equal duration of effect.