Insecticide induced acute neurobehavioural changes in rats and mice
Agarwal, A.K.; Sankaranaryanan, A.; Sharma, P.L.
Indian Journal of Medical Research 88: 91-98
1988
ISSN/ISBN: 0019-5340 PMID: 3182040 Document Number: 17170
Neurobehavioural changes after acute exposure to insecticides have been studied in albino rats and mice. Aldrin (organochlorine), phosphamidon (organophosphate) and propoxur (carbamate) were tested at one-fourth the LD50 dose for their effects on audiogenic immobility, fighting behaviour, despair behaviour and morphine analgesia. Locomotor activity increased, and latency and freezing time decreased after aldrin treatment whereas, reverse effect was observed with the other two compounds. Fighting behaviour was aggravated by aldrin, and immobility time of despair behaviour was significantly increased by phosphamidon and propoxur. Morphine analgesia was not affected by any of the treatments. It is concluded that organochlorines cause stimulation whereas, organophosphate and carbamate insecticides lead to depression of CNS, on acute non-lethal exposure.
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