Hematological changes related to coagulation in toxemia of pregnancy --in reference to postpartum hemorrhage
Fuse, Y.; Shirai, T.
Acta Obstetrica et Gynaecologica Japonica 33(4): 506-512
1981
ISSN/ISBN: 0001-6330 PMID: 6972144 Document Number: 170873
Toxemia of pregnancy is chronic DIC (mm/l h) was 43.3 .+-. 14.4 in toxemia of pregnancy, 46.4 .+-. 4.8 in A group, 40.6 .+-. 4.6 in B group, and 31.0 in C group. BSR in toxemia of pregnancy did not differ from that in normal pregnancy, but it varied with the blood loss volume. Plasma factor XIII was 9.45 .+-. 1.85 .mu.M-malate dehydrogenase/10 min in toxemia of pregnancy, reduced as compared with that in normal pregnancy, and subunit A and S were also reduced in which the decrease was more marked in groups of greater blood loss. Prothrombin time and active partial thromboplastin time were prolonged more markedly as the volume of blood loss increased. Platelet ADP aggregation (%) was accelerated to 82.2 .+-. 7.9 in toxemia of pregnancy, and 87.9 .+-. 6.91 in A group, 81.6 .+-. 7.42 in B group and 69.8 .+-. 4.89 in C group. Platelet spreadability (.mu.) was accelerated to 9.76 .+-. 0.16 in toxemia of pregnancy, while it was 9.83 .+-. 0.13 in A group, 9.77 .+-. 0.16 in B group and 9.68 .+-. 0.23 in C group, gradually declining with increase in blood loss volume. Apparently DIC becomes more marked as the postpartum blood loss volume increases.