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Features of hematopoiesis in mice protected from the lethal effect of cytosar by deoxycytidine

Belianchikova, N.I.; Bukhman, V.M.; Barkhotkina, M.F.

Biulleten' Eksperimental'noi Biologii i Meditsiny 91(1): 67-69

1981

ISSN/ISBN: 0365-9615
PMID: 7214011
Document Number: 170481
Simultaneous administration to B6 female mice of deoxycytidine in doses exceeding 2--3-fold those of cytosar (20 mg/kg three times a day for 4 days) prevents lethal toxicity induced by cytosar, protects the bone marrow and spleen, hemopoietic stem cells, myeloid and erythroid cells of the bone marrow, spleen and blood. It also protects spleen and blood lymphocytes from cytosar toxic effect by does not protect thymus or bone marrow lymphocytes.

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