Mutagenesis and morphological transformation of mammalian cells by a non-bay-region polycyclic cyclopenta(cd)pyrene and its 3,4-oxide

Gold, A.; Nesnow, S.; Moore, M.; Garland, H.; Curtis, G.; Howard, B.; Graham, D.; Eisenstadt, E.; Gold, A; Nesnow, S; Moore, M; Garland, H; Curtis, G; Howard, B; Graham, D; Eisenstadt, E

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Mutagenesis and morphological transformation of mammalian cells by a non-bay-region polycyclic cyclopenta (cd) pyrene and its 3,4-oxide

Gold, A.; Nesnow, S.; Moore, M.; Garland, H.; Curtis, G.; Howard, B.; Graham, D.; Eisenstadt, E.

Cancer Research 40(12): 4482-4484

1980

ISSN/ISBN: 0008-5472

PMID: 7438080

Document Number: 168181

Cyclopenta(cd)pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to be a direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide may be an ultimate mutagenic form of the parent hydrocarbon.