Combined carcinogenic action of chrysotile asbestos dust and N-nitrosodiethylamine on the respiratory tract of Syrian golden hamsters
Küng-Vösamäe, A.; Vinkmann, F.
Iarc Scientific Publications 30: 305-310
1980
ISSN/ISBN: 0300-5038 PMID: 7239649 Document Number: 168095
The combined carcinogenic activity of intratracheally inoculated Canadian chrysotile asbestos dust and orally or subcutaneously administered NDEA has been studied in long-term experiments in Syrian golden hamsters. In animals treated with asbestos only, no lung tumours developed, and single tracheal or laryngeal papillomas were found in only a very few cases. In animals treated with asbestos and NDEA, a synergistic effect which increased the incidence of lung tumours was observed.