Cellular basis of the hematopoietic microenvironment
Fridenshteĭn, A.I.; Luriia, E.A.
Terapevticheskii Arkhiv 52(9): 67-71
1980
ISSN/ISBN: 0040-3660 PMID: 7001663 Document Number: 167891
The reproduction and maturation of the hemopoietic and lymphoid cells in mice involve regular transfer of their precursor cells from some organs of the hemopoietic system to others. In each organ the hemopoietic cells pass through certain developmental stages and are exposed to the effects of local differentiative factors. The combination of these factors forms the hemopoietic microenvironment of the respective organ of hemopoiesis or immunity. Stromal mechanocytes (fibroblasts) of the hemopoietic organs are responsible for the formation of the special hemopoietic microenvironment. They are capable of transferring hemopoietic microenvironment in cases of heterotopic transplantation. In such newly created hemopoietic and lymphoid organs the recipient's hemopoietic cells develop in accordance with the program transferred from the donor by his stromal mechanocytes. In a number of cases this may lead to substantial changes of the hematological and immunological state, e.g., to compensation of genetic defects of hemopoiesis or to changing the type of the immune response to certain antigens. Besides the cells that form and transfer the microenvironment there are effector cell structures that produce the microenvironment factors. These are, in particular, intraorgan vessels of the hemopoietic system and the osteogenic tissue for the bone marrow microenvironment.