Studies on the renal function in open heart surgery under simple deep hypothermia
Oikawa, Y.
Nihon Kyobu Geka Gakkai 28(2): 186-199
1980
ISSN/ISBN: 0369-4739 PMID: 7381245 Document Number: 167892
Renal function studies were made in 15 patients who underwent open heart surgery performed under simple deep hypothermia. During the period of cooling, there was a progressive decrease in blood pressure, glomerular filtration rate and urine volume. Renal tubular reabsorption was not influenced by cooling, and the cause of decrease in urine volume was thought to be due to transient oligouria. During rewarming, urine volume increased as blood pressure rose. Even when the body temperature returned to the precooling level, the glomerular filtration rate returned to only about 55% of the control level. The renal tubular function during rewarming was decreased in comparison with that of the cooling period. The changes of renal function seen during rewarming can be attributed to the increase in catecholamine secretion. Evidently the function was not influenced by antidiuretic hormone and aldosterone during cooling and rewarming. Most of the renal function tests returned to the normal levels approximately 6 h postoperatively, but recovery of tubular reabsorption of electrolytes was delayed for 1-2 days. In the majority of the cases, H2O and electrocyte metabolism after open heart surgery performed under simple deep hypothermia was normalized until the 3rd postoperative day.