Clinical observations on the rheological and hemodynamic effects of some drugs acting on the microcirculation
Motta, G.; Ratto, G.B.
Minerva Medica 71(19): 1367-1376
1980
ISSN/ISBN: 0026-4806 PMID: 6155647 Document Number: 167682
A clinical research was carried out on the rheological and haemodynamic effects of various drugs commonly employed in the treatment of certain disturbances of the microcirculation. In addition to low molecular weight dextrane, a comparison was also made of three other substances theoretically capable of interfering with the fundamental relationship between viscosity, volume and haemodynamics. Assessment of the clinical signs was made both via evaluation of the peripheral haemodynamics during rest and during post-ischaemic hyperaemia and through determination of changes in blood viscosity by means of an original capillary viscosimeter. Some conclusions of a certain speculative and practical interest are drawn from the research as a whole.