Two populations of Ia-like molecules on a human B cell line
Lampson, L.A.; Levy, R.
Journal of Immunology 125(1): 293-299
1980
ISSN/ISBN: 0022-1767 PMID: 6966655 Document Number: 167140
Evidence is presented for two populations of Ia-like molecules on the human B cell line Raji. Two monoclonal antibodies, L203 and L227, are described. Both recognize nonpolymorphic determinants on B cell antigens. Both immunoprecipitate 34,000- and 28,000-dalton material from 125I-labeled extracts of Raji, but L227 precipitates 25,000-dalton material as well. Immunodepletion experiments confirm that the antibodies react with two different populations of molecules.
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