New experimental model of meningeal leukemia
Peterson, R.D.; Varakis, J.N.; Cheshire, L.B.
Cancer Research 40(9): 3130-3133
1980
ISSN/ISBN: 0008-5472 PMID: 7427931 Document Number: 165873
Meningeal leukemia is a common, often fatal complication of leukemia. Efforts to devise better prophylactic or therapeutic regimens have been limited by large gaps in knowledge regarding the pathogenesis of the process. A new experimental model of meningeal leukemia that should facilitate its study and fill some of the gaps is described. T[thymus-derived]-cell lymphomas, originally induced in C3H mice by Gross murine leukemia virus, were established as transplantable tumor lines in syngeneic mice. Three of 10 tumor lines produced meningeal leukemia when injected i.v. into normal recipient animals. The others produced predominantly visceral lymphomas.