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Evidence for abnormalities in separate lymphocyte populations in NZB mice

Taurog, J.D.; Smathers, P.A.; Steinberg, A.D.

Journal of Immunology 125(2): 485-490

1980

ISSN/ISBN: 0022-1767
PMID: 6967080
Document Number: 165158
Neonatally thymectomized, lethally irradiated NZB .times. DBA/2 and DBA/2 .times. NZB F1 mice were reconstituted with NZB or DBA/2 bone marrow cells and NZB or DBA/2 thymocytes. Of the 4 resulting groups of recipient F1 mice, those given NZB bone marrow cells developed high serum IgDNA; the highest anti-ssDNA responses occurred in recipients of both NZB bone marrow cells and NZB thymocytes. Functional abnormalities in separate lymphocyte populations apparently underlie different immune abnormalities in NZB mice.

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