High molecular weight lymphocyte surface proteins are structurally related and are expressed on different cell populations at different times during lymphocyte maturation and differentiation
Sarmiento, M.; Loken, M.R.; Trowbridge, I.S.; Coffman, R.L.; Fitch, F.W.
Journal of Immunology 128(4): 1676-1684
1982
ISSN/ISBN: 0022-1767 PMID: 6460808 Document Number: 191751
HMW lymphocyte surface proteins T20 and B220, which are expressed on T and B cells, respectively, have been found to be extensively related in structure, beyond what would be expected by the sharing of the determinant detected by monoclonal antibody 13/2. In addition, another HMW protein (T200A) has been discovered, which is preferentially expression proliferating T cells, and which exhibits significant structural homology with T200, but does not express the 13/2 determinant. T200A bears a novel antigenic determinant, detected by monoclonal antibody BS-S28E, which is not shared by either T200 or B220. A fourth HMW protein (170/100) has been found, which is expressed on most lymphocytes, but which is neither structurally nor antigenically related to T200A, T200, or B220. Monoclonal antibodies reactive with 170/100 inhibit T cell-mediated cytolysis, although monoclonal antibodies reactive with T200A, T200, or B220 do not.