Chronobiological aspects of artificial total heart replacement in long-term animal experiments--a systemanalytic study
Unger, V.; Grosse-Siestrup, C.; Gerlach, K.; Kuhlmann, F.; Affeld, K.; Hennig, E.; Keilbach, H.; Bücherl, E.S.
Wiener Medizinische Wochenschrift 130(2): 86-90
1980
ISSN/ISBN: 0043-5341 PMID: 6992466 Document Number: 164658
Biological rhythms (circadian rhythms) have been observed in the hemodynamics of experimental animals (calves). After artificial total heart replacement these rhythms are typically altered compared to control animals. These observations induce a growing consideration of chronobiological aspects in a systemanalysis for the conception of an automatic external control of the artificial heart, which has to be divided in:--parameter-progression (tendencies), --parameter-variation (discrete, oscillations), --parameter-coupling (phase shifts).