Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH

Iida, H.; Inamori, M.; Okuno, K.; Sekino, Y.; Sakai, E.; Okubo, H.; Higurashi, T.; Endo, H.; Hosono, K.; Yoneda, M.; Koide, T.; Takahashi, H.; Goto, A.; Kubota, K.; Saito, S.; Maeda, S.; Nakajima, A.; Gotoh, E.

Hepato-Gastroenterology 62(138): 493-496

2015


ISSN/ISBN: 0172-6390
PMID: 25916088
Document Number: 16443
The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral dose of a proton pump inhibitor, esomeprazole 20 mg and omeprazole 20 mg. A total of 14 Helicobacter pylori-negative male subjects participated in this study. Intragastric pH was monitored continuously for 6 hours after a single oral dose of omeprazole 20 mg and a single oral dose of esomeprazole 20 mg. Each administration was separated by a 7-day washout period. During the 6-hour study period, the average pH after administration of esomeprazole was higher than that after the administration of omeprazole. Also during the 6-hour study period, each of pH > 2, 3, 3.5, 4, and 5 was maintained for a longer duration after administration of esomeprazole 20 mg than after administration of omeprazole 20 mg (median: 75.4% vs. 53.8%, p = 0.0138; 52.1% vs. 33.4%, p = 0.0188; 45.8% vs. 28.2%, p = 0.0262; 42.5% vs. 20.7%, p = 0.0414; 35.8% vs. 11.6%, p = 0.0262; respectively). In Helicobacter pylori-negative healthy male subjects, single oral administration of esomeprazole 20 mg increased the intragastric pH more rapidly than single oral administration of omeprazole 20 mg.

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Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH