The effect of cycloheximide and carbon tetrachloride in Ehrlich ascites tumour-bearing mice
Parry, E.W.
Gan 71(3): 275-279
1980
ISSN/ISBN: 0016-450X PMID: 7418971 Document Number: 163589
Treatment with cycloheximide and a hepatotoxic dose of CCl4 (well tolerated in normal animals) is acutely toxic in animals bearing the Ehrlich ascites tumour. Reduction in tumour load 4 hr after the administration of cycloheximide and CCl4 is life-saving: treatment with a hepatotoxic dose of CCl4 30 hr before challenge with cycloheximide and CCl4 also nullifies that otherwise life-threatening treatment.
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