Cytostatic and cytopathogenic effect of 1,4-dioxyquinoxaline and its derivatives on human fibroblast cell cultures in vitro
Truchlinski, J.; Jabłoński, L.
Medycyna Doswiadczalna i Mikrobiologia 32(3): 221-227
1980
ISSN/ISBN: 0025-8601 PMID: 7206905 Document Number: 163395
1,4-Dioxyquinoxalin, 2-N-2-hydroxyethylcarbamoyl-(3-methyl-)1,4-dioxyquinoxalin and 3-methyl(2-methylene)-1,4-dioxyquinoxalin, which are stimulators of animal growth and development, were tested for their effect on human fibroblast cells in vitro, in doses of 12.5 and 200 ppm. Cytopathogenic effect was revealed, with intranuclear changes particularly expressed. The 3 compounds exerted a marked effect on cell morphology and physiology. Fibroblast cells acted upon by the first 2 compounds, then passaged 3 times without them, underwent further degeneration and disappeared.