Top Abstract Purchase Related
Home
>
Node
>
Subnode

Ani immunomodulator Hepon inhibits hepatitis C virus replication in human cell cultures in vitro

Ataullakhanov, R.I.; Holms, R.D.; Katlinskiĭ, A.V.; Deriabin, P.G.; Narovlianskiĭ, A.N.; Mezentseva, M.V.; Ershov, F.I.

Antibiotiki i Khimioterapiia 47(8): 9-11

2002

ISSN/ISBN: 0235-2990
PMID: 12515090
Document Number: 547163
Antiviral activity of immunomodulator "Hepon" was evaluated in human cells culture infected with hepatitis C virus. "Hepon" presence protected human cells SW-13 from cytopathogenic effect of hepatitis C virus. Maximum antiviral effect was demonstrated by "Hepon" at concentration 1 mcg/mL. Control antiviral agent reaferon (interferon alfa-2a) was more potent as vitality protecting agent in the case of SW-13 human cells culture. "Hepon" activity is based on changes of cytokins and interferons spectrum so this immunomodulator is expected to be effective against different viruses including herpes virus and encephalocarditis virus.

Document emailed within 1 workday
Secure & encrypted payments

Santos-López, G.; Vallejo-Ruiz, V.ón.; Reyes-Leyva, J. 2007: Hepatitis C virus replication in vitro Gaceta Medica de Mexico 143(4): 351-352
Stauber, E.H.; Whitbeck, V.; Bull, R.C. 1983: Variation of virus replication in primary bovine kidney cell cultures derived from 68 three-day-old calves American Journal of Veterinary Research 44(12): 2376-2378
Bouroncle, B.A.; Clausen, K.P.; Darner, E.M. 1970: Replication of herpes simplex virus in cultures of phytohemagglutinin-stimulated human lymphocytes Journal of the National Cancer Institute 44(5): 1065-1078
McCormick, J.B.; Getchell, J.P.; Mitchell, S.W.; Hicks, D.R. 1984: Ribavirin suppresses replication of lymphadenopathy-associated virus in cultures of human adult T lymphocytes Lancet 2(8416): 1367-1369
Coudert, F.; Cauchy, L. 1975: Virus replication and cell modifications in organ cultures of tumor tissue from chickens with Marek's disease Journal of the National Cancer Institute 55(1): 47-51
Rosztóczy, I. 1978: Effect of interferon and poly I:C on replication of influenza virus in organ cultures of human origin Acta Virologica 22(3): 235-237
Zhirnov, O.P.; Vorob'eva, I.V.; Safonova, O.A.; Malyshev, N.A.; Schwalm, F.; Klenk, H.-D. 2013: Pathogenic effect of pandemic influenza virus H1N1 under replication in cultures of human cells Voprosy Virusologii 58(4): 20-28
Mankertz, J.; von Baeyer, H.; Rokos, K.; Nündel, M.; Pauli, G.; Riedel, E. 1995: Cell specific uptake of antiretroviral drugs: AZT coupled to LDL inhibits HIV replication in human macrophages International Journal of Clinical Pharmacology and Therapeutics 33(2): 85-88
Rector, W.G.; Govindarajan, S.; Horsburgh, C.R.; Penley, K.A.; Cohn, D.L.; Judson, F.N. 1988: Hepatic inflammation, hepatitis B replication, and cellular immune function in homosexual males with chronic hepatitis B and antibody to human immunodeficiency virus American Journal of Gastroenterology 83(3): 262-266
Granzow, H.; Schirrmeier, H.; Beyer, J.; Lange, E. 1988: Morphologic studies of virus infection of the intestinal tract--virus replication and cytopathology in cell cultures and enterocytes in piglets. 1. Ultrastructure of intestinal epithelium without viral infiltration and in rotavirus infection Archiv für Experimentelle Veterinarmedizin 42(4): 558-570
Aspinall, S.; Alexander, J.J. 1985: Hepatitis B virus gene expression in two cell lines, one derived from a natural human infection, the other experimentally infected in vitro South African Medical Journal 68(10): 751-754
McGrath, C.M. 1971: Replication of mammary tumor virus in tumor cell cultures: dependence on hormone-induced cellular organization Journal of the National Cancer Institute 47(2): 455-467
Bal, E.; Puricelli, L.; de la Peña, N.C.; de Lustig, E.S. 1979: Influence of human leukocyte interferon on IgG on the replication of herpes simplex virus in nervous tissue in vitro Acta Virologica 23(6): 461-467
Bian, Z.-q.; Liu, S.; Liu, M.-q.; Xiao, A.; Jiao, Y.; Yan, W.-y.; Zheng, Z.-x. 2012: PreC/C gene-targeting RNA interference suppresses hepatitis B virus replication and expression in human hepatoma cells Zhonghua Yi Xue Za Zhi 92(11): 768-772
Zuckerman, A.J. 1972: Propagation of the serum hepatitis virus in human liver organ cultures Gut 13(4): 318-319
Grabowska, G.; Wiśniewski, J. 1989: Effects of IPO-63, Carbaryl, Foschlor and Reglone on Newcastle disease virus replication in chick embryo and chick embryo cell cultures Medycyna Doswiadczalna i Mikrobiologia 41(1): 47-52
Favre, D.; Berthillon, P.; Trépo, C. 2002: In vitro hepatitis C. Elimination of lipoproteins associated with cells: an important stage to obtain an efficient infection of human hepatocytes by the hepatitis C virus Revue Medicale de la Suisse Romande 122(4): 205
Narovlianskiĭ, A.N.; Deriabin, P.G.; Vershinina, M.I.; Mezentseva, M.V.; Ershov, F.I. 2002: Effect of interferon inductors on infection induced by hepatitis C virus and activity of mRNA cytokines in cell cultures SW-13 and MT-4 Voprosy Virusologii 47(6): 17-21
Grófová, M.; Popovic, M.; Matoska, J.; Nilsson, K.; Vlasenkova, N.K.; Thurzo, V. 1979: Preferential replication of murine xenotropic type-C virus in human lymphosarcoma-derived cell lines Neoplasma 26(3): 241-250
Bartolomé, J.; Castillo, I.; Mora, I.; Gutiez, J.; Porres, J.C.; Carreño, V. 1988: Different levels of hepatitis B virus replication among hepatitis be antigen-positive chronic carriers Acta Virologica 32(3): 193-197