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Comparative effects of two commercially available blood collection tubes on plasma concentrations of drugs

Steyn, J.M.; Müller, F.O.

South African Medical Journal 57(4): 129-131

1980

ISSN/ISBN: 0256-9574
PMID: 6773155
Document Number: 163360
Two commercially available blood collection systems (Venoject and Vacutainer) were investigated for their effect on the plasma concentrations of a variety of drugs. Vacutainer tubes adversely affected the following drugs: propranolol, penbutolol and quinidine, whereas Venoject tubes had no effect on the plasma concentrations of these drugs. Neither collection system had any effect on the plasma concentrations of the following drugs: acebutolol, the main metabolite of acebutolol (DL-1-(2-acetyl-4-acetamidophenoxy)-2-hydroxy-3-isopropylaminopropane), diazepam, N-demethyldiazepam, digoxin, ethosuximide, salicylic acid, valproic acid, warfarin and carbamazepine.

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