Effect of ouabain on urinary output of potassium in rats loaded with NaCl
Monma, Y.; Okuoka, Y.; Tanabe, T.
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 76(4): 265-270
1980
ISSN/ISBN: 0015-5691 PMID: 7450619 Document Number: 163148
Ouabain-induced kaliuresis was investigated in rats loaded with 1% NaCl (3 ml/100 g body weight, p.o.). The intraperitoneal administration of ouabain produced an increase in potassium excretion and a decrease in sodium excretion in doses over 1 mg/kg. The effect of ouabain in altering the electrolyte pattern of urine was more marked in NaCl-loaded rats than in water-loaded (3 ml/100 g body weight, p.o.) rats. At doses of 10 mg/kg, ouabain produced a significant decrease in excretions of sodium and H+ and equalized the output of sodium with that of potassium in terms of concentration and total output. Thus, factors other than the ion exchange mechanism in distal tubules appear to be responsible for the ouabain-induced kaliuresis, when the drug is given to rats in high doses.