Kainic acid induced lesion of ventral tegmental area: locomotor effect of apomorphine
Morgenstern, R.
Acta Biologica et Medica Germanica 39(8-9): 911-915
1980
ISSN/ISBN: 0001-5318 PMID: 7282221 Document Number: 163031
Kainic acid induced lesion of dopaminergic ventral tegmental area (KA-A10) result in a permanent behavioral syndrome in the rat in which locomotor hyperactivity is the most typical symptom. Apomorphine in low doses (0.125 and 0.25 mg/kg i.p.) was as active as haloperidol (0.25 mg/kg i.p.) in abolishing this locomotor hyperactivity while higher doses of apomorphine were less active. The KA-A10 lesion is discussed as a model of mesolimbic/mesocortical dopaminergic hyperactivity.
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