Influence of piridoxilate on the energy metabolism of normothermic ischemic organs in the rat
Fischer, J.H.
Arzneimittel-Forschung 30(12): 2132-2134
1980
ISSN/ISBN: 0004-4172 PMID: 7194075 Document Number: 162923
In Wistar rats thermocontrolled normothermic ischemia of the whole body was induced 20 min after i.p. injection of 300 mg piridoxilate (Glyco-6) per kg body weight or Ringer's solution in a control group. Piridoxilate pretreatment did not influence the amount of total adenine nucleotide loss in 30 min of normothermic ischemia of forebrain, skeletal muscle, liver or kidney but resulted in a significantly higher loss in myocardium and lung. A positive effect on the conversation of energy rich substances was found only in the skeletal muscle (creatine phosphate content). Significant effects on substrates of glycolysis were found only in myocardium and lung but in the myocardium also a higher accumulation of lactate occurred.