Influence of local anesthetics and narcotics on the energy metabolism of Ehrlich ascites tumor cells
Buttgereit, F.; Müller, M.; Rapoport, S.M.
Biomedica Biochimica Acta 49(1): 3-10
1990
ISSN/ISBN: 0232-766X PMID: 2113804 Document Number: 362969
The suitability of Ehrlich ascites tumour cells as a test object for potential drugs affecting ATP-producing or consuming processes directly or indirectly is made likely by actions of local anesthetics and narcotics on the energy metabolism of these cells. The influence of local anesthetics on cation transport and Ca+(+)-dependent processes as well as the inhibition of NADH-ubiquinone reductase by narcotics is demonstrated for Ehrlich ascites tumour cells, too.