Prediction of response to antihypertensive therapy with prazosin
MacCarthy, E.P.; Frost, G.W.; Monaghan, J.C.; Mennie, B.A.; Stokes, G.S.
Medical Journal of Australia 2(Sp1): 12-14
1980
ISSN/ISBN: 0025-729X PMID: 7421719 Document Number: 162715
Blood-pressure responses and changes in plasma drug concentration were studied in 11 hypertensive patients after an initial oral dose of 2 mg of prazosin. Subsequently, blood pressure was monitored during long-term treatment with prazosin. The prazosin reactivity index, a value derived during the first-dose study, appeared to predict the long-term antihypertensive effect of prazosin alone or prazosin combined with bendrofluazide.
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