Two cases of scleromyxedema
Jepsen, L.V.
Acta Dermato-Venereologica 60(1): 77-79
1980
ISSN/ISBN: 0001-5555 PMID: 6153843 Document Number: 159767
We report two cases of scleromyxedema treated with melphalan (alkeran) and dermabrasion, both patients with central nervous system involvement. In the first case, herpetic encephalitis, possibly due to the immunoglobulin disturbance, preceded the skin changes. In the second case, impaired cerebral function was caused by a meningeoma. In the first case of short duration it seems as if progression of the disease has been arrested. In the second, of more than 26 years duration the skin changes have seemed unchanged, sclerotic for some years, though some improvement was noticed following dermabrasion.