Scleromyxedema presenting with neurologic symptoms: a case report and review of the literature
Marshall, K.; Klepeiss, S.A.; Ioffreda, M.D.; Helm, K.F.
Cutis 85(3): 137-140
2010
ISSN/ISBN: 0011-4162 PMID: 20408512 Document Number: 647545
Scleromyxedema is a rare variant of lichen myxedematosus. In addition to cutaneous manifestations, scleromyxedema often presents with systemic manifestations, including dysphagia, proximal muscle weakness, central nervous system disturbances, encephalopathy, and restrictive lung disease. It is almost always associated with paraproteinemia, usually IgG with gamma light chains. We review the literature on scleromyxedema associated with neurologic symptoms and present a case of a 49-year-old woman with encephalopathy attributable to scleromyxedema.