Neurotoxicity of mitotane therapy of adrenocortical carcinoma (5 cases) and Cushing's syndrome (7 cases)
Du Rostu, H.; Krempf, M.; Mussini, J.M.; Murat, A.; Guillon, J.; Charbonnel, B.
Presse Medicale 16(19): 951-954
1987
ISSN/ISBN: 0755-4982 PMID: 2954144 Document Number: 305374
Twelve patients were treated with op'DDD over a 9-year period. All presented with mild neurological symptoms, and half of them had major complications. There was no relation between the occurrence of these symptoms and the dose or duration of op'DDD therapy. The mechanisms of this neurological toxicity, both central and peripheral, are not well known, but they appear to be similar to those of certain op'DDD-related chemicals used in industry.