Plasma and urinary catecholamines and metabolites during physical exercise in essential hypertension
Chodakowska, J.; Wocial, B.; Skórka, B.; Nazar, K.; Chwalbińska-Moneta, J.
Acta Physiologica Polonica 31(6): 623-630
1980
ISSN/ISBN: 0044-6033 PMID: 6787836 Document Number: 159753
The effect of physical exercise on plasma catecholamines and urinary catecholamines and metabolites was studied in 11 patients with established essential hypertension, 5 patients with borderline hypertension and 9 healthy volunteers. Resting plasma noradrenaline found in established hypertension were associated with its diminished urinary clearance. Altered renal handling of adrenaline in essential hypertension is suggested. Physical exercise was associated with enhancement of metabolism of noradrenaline to 3-methoxy-4-hydroxyphenylglycol in all groups. The stimulation of this pathway was particularly pronounced in healthy subjects. In the essential hypertension the pattern of urinary excretion of catecholamines and metabolites suggests impaired noradrenaline metabolism during exercise. The only characteristic feature of borderline, as opposed to established hypertension, was the increased urinary excretion of dopamine.